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Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis activities, and compound 6 demonstrated antiangiogenesis activity. This fungal species can cause a human hemorrhagic disorder known as onyalai. In this study, we identified the active components with antiplatelet ...
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Abstract. Antiplatelet agents, with aspirin and P2Y 12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular …
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To confirm that aspirin suppositories are an effective treatment for acute ischemic stroke, we examined the suppressive effects of 200-mg aspirin suppositories on platelet aggregation. Aspirin suppositories suppressed platelet aggregation induced by ADP or collagen, and the suppression continued for …
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Aspirin has significantly reduced morbidity and mortality related to coronary artery disease and is considered as the most cost-effective drug for secondary prevention of coronary artery disease [1].Aspirin is a first-line antiplatelet aggregation drug widely recognized for all types of platelet-dependent thrombotic vessel occlusion [2].Aspirin is a non-selective …
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In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. We have reported and discussed here the antiplatelet aggregation properties of the eleven naturally-occurring phenanthrenes (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically synthesized phenanthrenes (18-35).
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3.3.. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirinA comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.
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Antiplatelet therapy plays a critical role in the prevention and treatment of major cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in reducing morbidity and death caused by …
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Platelet aggregation inhibitors/antiplatelets - clopidogrel, abciximab. Platelet aggregation inhibitors are a class of drugs that decrease platelet aggregation and inhibit thrombus formation. Platelet aggregation is the clumping together of platelets in the blood and is part of the sequence of events leading to the formation of a thrombus or clot.
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Dipyridamole inhibits platelet aggregation in whole blood, as assessed by impedance aggregometry, but not in platelet-rich plasma both in vitro and ex vivo, by blocking the reuptake of adenosine [72, 73]. A stronger antiplatelet effect of dipyridamole in whole blood than in plasma was confirmed using different laboratory methods [74–77].
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Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major …
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The MeOH extract of the stem of Dendrobium loddigesii was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid and collagen. Two active compounds, moscatilin [1] and moscatin [2], were isolated. Moscatilin diacetate [3] …
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Antiplatelet drugs provide first-line antithrombotic therapy for the management of acute ischemic syndromes (both coronary and cerebrovascular) and for the prevention of their recurrence.
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Antiplatelet drug mechanisms of action. The thienopyridines clopidogrel and prasugrel prevent ADP from binding its specific P2Y 12 receptor and cause its irreversible inhibition; ticagrelor exerts reversible P2Y 12 receptor antagonism. While clopidogrel and prasugrel require hepatic metabolism to produce the active drug metabolite, ticagrelor is not a prodrug and has a direct …
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Antiplatelet therapy improves prognosis in patients with cardiovascular disease. Bleeding is a major complication of antiplatelet therapy and is associated with an increased risk of death.
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Antiplatelet agents are drugs that inhibit enzymes or receptors required for platelet activation, platelet aggregation, and/or thrombus formation. The most commonly used antiplatelet agent is acety...
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Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction (heart attacks), stent thrombosis, and ischemic stroke (strokes caused by a blood clot).
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Antiplatelet and anticoagulant drugs, used alone or in combination, are a cornerstone of clinical treatment for human diseases associated with increased athero/thrombotic risks, such as heart attack and stroke, and in preventing thrombosis during surgery or other medical procedures involving vascular disruption or perturbed blood flow. 1 – 6 The …
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blished because of the high-throughput characteristic, but it needs more practical applications. Objectives: To evaluate the microtiter plate method by using aspirin and clopidogrel in vivo and in vitro. Methods: In vitro, the platelet aggregations inhibited by aspirin (0.3, 1, 3, 10, 30, 90 μM) and clopidogrel (1, 3, 10, 30, 100, 300 μM) were evaluated with the presence of arachidonic acid ...
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antiplatelet drug, any drug that interferes with the aggregation of platelets and formation of a clot (thrombus) in a blood vessel.Clot formation in coronary arteries may cut off the blood supply to a region of the heart and cause a myocardial infarction (heart attack). When administered during a heart attack, antiplatelet drugs can reduce the extent of damage to the heart muscle and the ...
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Antiplatelet agents inhibit clot formation by preventing platelet activation and aggregation, while anticoagulants primarily inhibit the coagulation cascade and fibrin formation. Therapeutics within each category differs with respect to the mechanism of action, time to onset, duration of effect and route of administration.
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Aggregation: Activated platelets bind together through receptors on their surface that interact with fibrinogen—a soluble plasma protein that acts as a glue for platelets. This clumping forms a platelet plug. ... Antiplatelet Therapy: Used primarily for patients at risk for cardiovascular events. Medications such as aspirin inhibit ...
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Antiplatelet drugs are primarily directed against platelets and inhibit platelet activation by a number of different mechanisms. They are used for the prevention and treatment of thrombotic processes, especially in the arterial vascular system. ... aggregation, and thrombus formation on subendothelial surface at an injured blood vessel. After ...
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Platelet Aggregation Inhibitors decrease platelet aggregation and inhibit thrombus formation. They are effective in the arterial circulation, where anticoagulants have little effect. They are widely …
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The study of platelet aggregation has several clinical applications, including the diagnosis and treatment of thrombotic disorders. Platelet aggregation studies are used to diagnose platelet function disorders, such as thrombocytopenia and platelet dysfunction, and to monitor the effectiveness of antiplatelet therapies.
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Antiplatelet aggregation constituents from Annona purpurea J Nat Prod. 1998 Dec;61(12):1457-61. doi: 10.1021/np9800046. Authors F R Chang 1, J L Wei, C M Teng, Y C Wu. Affiliation 1 Graduate Institute of Natural ...
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Antiplatelet therapy reduces the risk of thrombosis and its consequences, including death and myocardial infarction (MI). Platelet activation and aggregation in response to endothelial injury is a crucial part of the pathophysiology of ACS, and various antiplatelet therapies target different platelet receptors . Antiplatelet medications are ...
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Antiplatelet agents are drugs used to prevent the formation of blood clots that can lead to heart attack and stroke. Antiplatelet drugs block a substance called thromboxane A2, which is …
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This review suggests that garlic and its preparations have a beneficial effect against thrombosis and have an antiplatelet aggregation property. However, with the very vast literature on garlic ...
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Clinical Pharmacology of Antiplatelet Drugs. Multiple pathways contribute to platelet activation and aggregation, and although pharmacological interference with these pathways reduces the risk of atherothrombotic complications, it is also associated with an increased risk of bleeding ().It is important to emphasize that the thromboxane (TX) A 2-, adenosine diphosphate (ADP)-, and …
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